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العنوان
Use of phytoestrogen with clomiphene citrate for ovulation induction in polycystic ovary syndrome /
المؤلف
Mohammed, Azhar Mohammed Farid.
هيئة الاعداد
باحث / أزهــار محمد فريد محمد
مشرف / شرويت محمد شوقي
مشرف / محمد ناجي محيسن
الموضوع
Phytoestrogens. Polycystic ovary syndrome.
تاريخ النشر
2018.
عدد الصفحات
58 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
الناشر
تاريخ الإجازة
8/1/2019
مكان الإجازة
جامعة بني سويف - كلية الطب - النساء والتوليد
الفهرس
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Abstract

summary
polycystic ovary syndrome (PCOS) is acommon endocrine disorder. The prevalence of this disorder is from 6% to 20% in women of reproductive age depending on the diagnostic criteria used (Echiburu et al., 2016).
The prevalence of infertility in women with PCOS varies between 70and 80% according to The American Society for Reproductive Medicine . (FertilSteril , 2013).
Several methods have been effective for ovulation induction and fertility treatment in women with PCOS:-
-Weight loss , exercise, and life style modifications .
-It has been more than 50 years that CC is establishedas the first –line for ovulation induction in PCOS. it is believed to bemore convenient and cost-efficient.(Spritzer PM, et al, 2015)
Phytoestrogen are adiverse group of naturally occurring non-steroidal plantcompounds that have the ability to cause estrogenic and anti-estrogenic effect because of their structural similarity with estradiol (17-B-estradiol). (Taylor & Francis, 2005)
The aim of the study will be carried out to assess the effectiveness of phytoestrogen with clomiphene citrate for ovulation induction in women with polycystic ovarian syndrome to overcome the antiestrogenic effect of clomiphene on endometrium.
The study was carried out in Beni- Seuf University Hospital, where the patient were selected. It included two groups
group one included 50 women received CC only 50 mg orally started from day 3 for 5 days.
group two included 50 women received CC 50 mg orally started from day 3 for 5 days with phytoestrogen (Klimadynon) (20mg of cimifuga racemosa from day 1to12).
There was no significant difference between the two group regardingage,BMI, duration and type of infertility and ultrasonographic picture of PCOS.
In our study women received phytoestrogen had more dominant follicles than those who receive CC only (2.2±.7-1.6± 1) respectively P value(.002).
In our study women received phytoestrogen had more ovulation rate than those who receive CC only (100%-80%)respectively P value(.001).
Also women received phytoestrogen had more thicker endometrium (10.1± 1.1)than those who receive CC only (5.3±.75) P value(.001).
In our study women received phytoestrogen had more pregnancy rate than those who receive CC only (36%-18%) respectively P value(.043).