الفهرس 
Lichen planusOnly 14 pages are availabe for public view
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Abstract
Summary
Lichen planus (LP) is an inflammatory mucocutaneous condition with characteristic clinical and histopathological findings. It is a disorder of the stratified squamous epithelium affecting skin, oral and genital mucous membranes, nails, and scalp. Classic cutaneous LP typically presents as pruritic, polygonal, violaceous flat-topped papules and plaques. It is estimated to affect 0.5–2.0% of the general population.
In the oral cavity, the disease is somewhat different in clinical appearance than on the skin, and is characterized by lesions consisting of radiating white, grey, velvety, thread-like papules in a linear, annular and retiform arrangement forming typical lacy, reticular patches, rings and streaks. A tiny white elevated dot is present at the intersection of white lines known here as Wickham streaks as compared to Wickham striae in skin.
OLP is one of the most common oral mucosal lesions affecting 0.5% to 2% of the adult population. It mainly affects middle-aged and elderly, and is more prevalent in women than in men.
Epidermal growth factor (EGF) is a member of a family of peptide growth factors that activate the EGF receptors, and that the EGF/EGFR signalling pathway plays important roles in proliferation, differentiation and migration of a variety of cell types, especially in epithelial cells. Recently studies denote that EGF and its signalling pathway have extended to a broad range of biological and pathophysiological roles in development and in human diseases.
Despite the strong association of EGFR overexpression with oral carcinogenesis of oral potentially malignant lesions (OPML), few studies have analysed its expression in OLP, showing controversial results.
The aim of this study is to explain if there is a relationship between EGF level and pathogenesis of OLP by detecting the level of EGF in serum and tissue in OLP and comparing them to control healthy group.
This study was conducted on twenty-nine OLP patients and twenty volunteers of different age groups and both sexes.All Patients were subjected to detailed history taking and complete dermatological and oral examination. Serum and tissue samples are collected from all patients of both groups to assess level of EGF.
In conclusion, according to this study there is a strong correlation between EGF and OLP, but the previous studies done are not sufficient enough to explain this relation.
Finally, we recommend further studies should be done on large number of patients to explain the role of EGF in OLP whether it has a role in pathogenesis of OLP or it is a protective mechanism against development of OLP or play a role in cancerization of OLP.