الفهرس | Only 14 pages are availabe for public view |
Abstract Sepsis is defined as a clinical syndrome resulting from the presence of both infection and a systemic inflammatory response. Sepsis is still the leading cause of death in critically ill patients. Early diagnosis of sepsis is vital because rapid and appropriate therapy is associated with improved outcomes. SuPAR is the soluble form of urokinase plasminogen activator receptor (uPAR), a receptor mainly expressed on various immunologically active cells. uPAR is involved in plasminogen activation, cell adhesion and migration, all central aspects of inflammatory processes and it is upregulated in response to immune activation. Soluble urokinase-type plasminogen activator receptor serves as a stable and promising prognostic marker in critical ill patients to assess disease severity and mortality risk. High levels of suPAR are associated with increased risk of early mortality and reflect disease severity. The present study aimed to evaluate serum suPAR level and to clarify its prognostic impact in critically ill patients. suPAR was determined in 60 critically ill patients admitted to ICU by ELISA technique. In addition 20 apparently healthy individuals matched in age were included as a control group. Patients were followed for a period of 28 days. Patients and controls were subjected to the following: 1- History taking and careful clinical examination. 2- Routine laboratory investigations: Complete blood picture. |