الفهرس 
Introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Background: Acne vulgaris is a common disorder of pilosebaceous unit affecting mainly adolescents. Polycystic ovary syndrome (PCOS) is the most common female endocrinopathy, affecting 5-10% of the female population. Omentin1 (intelectin) has been identified as a major visceral (omental) fat secretor adipokine. Omentin-1 concentration was found to decrease in women with Poly Cystic Ovary Syndrome (PCOS) when compared with control subjects
Objectives: To measure Omentin-1 level in female patients with PCOS, resistant acne vulgaris, females with both diseases and healthy control females in order to detect the values of Omentin-1 in the pathogenesis of both diseases.
Methods: Our study was carried out on 60 patients 20 of them had resistant acne vulgaris; 20 had PCOS, 20 had both and 10 healthy sex and age matched volunteers as control group. Body Mass Index (BMI) was calculated and severity of acne and acne score were determined. Follicle Stimulating Hormone (FSH), Leutinizing Hormone (LH), Testosterone and Dehydroepiandrosterone Sulfate (DHEAS) levels were measured and omentin-1 level was measured using the Enzyme-Linked Immunosorbent Assay (ELISA) technique. Ultrasound was done to all patients and healthy controls
Results: Omentin-1 level was significantly lower in the patients groups (acne group, PCOS group and comorbid group) compared to control group (p= 0.033, p< 0.001, p< 0.001 respectively). Comorbid group had significantly lower Omentin-1 levels compared to acne group (p= 0.001). There was no statistical significant relation between Omentin-1 levels and severity or course of acne. Omentin-1 levels were not significantly associated with BMI or obesity.
Conclusion: Level of Omentin-1 in the acne group, PCOS group and comorbid group was significantly lower compared to the control group which may refer to a potential role of Omentin-1 in the pathogenesis of acne vulgaris and PCOS.
Key Words: Acne vulgaris- PCOS- Omentin-