الفهرس 
Alopecia AreataOnly 14 pages are availabe for public view
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Abstract
Alopecia areata (AA) is non-scarring hair loss resulting from an autoimmune disorder. Severity varies from patchy hair loss that often spontaneously resolves to severe and chronic cases that can progress to total loss of scalp and body hair. Reports have highlighted serum vitamin D deficiency and reduced 1,25-dihydroxyvitamin D(3) receptors (VDR) expression on hair follicles of alopecia areata (AA) patients.Vitamin D has a multitude of biologic effects interacting with the innate and adaptive immune system, mainly leading to its downregulation. Our aim is to compare the efficacy of topical calcipotriol versus oral vitamin D in alopecia areata. Fifty patients had localized (<5 patches and <40% scalp involvement) alopecia areata were categorized into two groups: for each group, one regime were used. Patients were subjected to full history, dermatological examination, measurement of vitamin D and dermoscopic examination for detecting thee degree of improvement in our study. Half of patients were treated with topical calcipotriol cream twice daily for 3 months and the other half received oral vitamin D daily for 3 months. The results of our study showed statistically significant difference with p-value < 0.05 between two study groups being better in topical calcipotriol group regarding degree of improvement of alopecia. After three months of treatment dermoscopic findings that explain signs of activity (Black dots, tapering hairs, yellow dots, broken hairs) of the disease were decreased, and signs of improvement (short vellus hairs, terminal hairs) were appeared. In topical calcipotriol group terminal hair was more than oral vitamin D group, in which signs of activity was still present in some cases. In conclution, Topical calcipotriol may be effective in the treatment of mild and moderate patchy (not more than 40% of scalp distribution) alopecia areata, oral vitamin D may be a main supplement in treatment of alopecia areata. There is no releation between serum vitamin D and efficacy of treatment. So, it is not recommended to measure vitamin D prior to treatment.