الفهرس 
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Abstract
Introduction
Acne vulgaris is a multifactorial inflammatory skin disease commonly affecting adolescents and young adults with considerable physical, psychological, and psychosocial burden on those affected . Acne is an increased sebum production due to the androgenic effect on the pilosebaceous unit leading to a chronic inflammatory disorder, microbial colonization by Propionibacterium acne, changed keratinization and inflammation of hair follicles in various areas of the body including the forehead, cheek, chest, neck, and back . No typical therapy for acne, however, a proper medical course for improving lesions can be established for most patients. Convenient local applications of remedies including benzoyl peroxide,retinoids, and antibiotics when utilized in combination usually enhance management of mild to moderate acne.
Dapsone, known as diaminodiphenyl sulfone, is an antibiotic routinely applied with rifampicin and clofazimine as a combination for leprosy therapy. It has antimicrobial and anti-inflammatory effects in diseases which are characterized by the accumulation of neutrophils. Moreover, it has been utilized for treatment of acne, dermatitis herpetiformis, and various other skin cases . It is available both topically and by mouth. However, dapsone can potentially cause severe side effects after oral administration, which may lead to the use of steroids or other antibiotics instead of dapsone to avoid its potential systemic toxicity, although these alternative medications are much less effective.
The aim of this study :
The present study was aimed at the formulation and evaluation of dapsone loaded niosomes for topical application with an objective to control and prolong the release of the drug with improved skin penetration for treatment of acne.
Patient study
The present study was conducted on 15 patients suffering from mild to moderate acne vulgaris according to the global acne grading score system . Patients were recruited from attendants of the Dermatology Outpatient Clinic, Minia University Hospital.
Exclusion criteria included pregnancy, lactation, presence of any skin condition that would interfere with the diagnosis or assessment of acne vulgaris, history of hypersensitivity or allergy to dapsone.
The results
The present study highlights the effect of a dapsone noisome as a topical once-daily treatment of mild to moderate acne vulgariswith early and maintained clinical improvement with minimal side effects.