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Abstract This study aimed to assess betatrophin expression in pregnant women with GDM diagnosed by OGTT and to evaluate their association with metabolic risk factors. Subjects were classified into: group I (Patients group): 50 pregnant women at 24-28 weeks of pregnancy with G.D.M attending to Minia University of Obstetric and Pediatric Hospital diagnosed by: Fasting blood glucose > 92 mg/dl. Oral glucose tolerance test: Blood glucose 1 hour after glucose load >180 mg/dl. Blood glucose 2h after glucose load > 153 mg/dl, with a single abnormal value. group II (Control group): 30 apparently healthy pregnant women. All the control participants were matched with patient population in terms of age and gestational age (24-28 weeks of pregnancy). All pregnant women included in the study were subjected to the following: 1-Complete history taking. 2- Clinical examination . 3-Laboratory Investigations: A-Routine investigations: Complete blood count (CBC) . Renal function tests. Liver function tests. Lipid profile. Fasting blood glucose. 1, 2 hour blood glucose after oral glucose load. B-Special: Betatrophin by enzyme immuno assay (EIA). As regarding comparison between group I and group II it was found that : There was significant increase in BMI in group I more than group II. There was significant increase in Hb level in group II more than group I. There was significant increase in TLC in group I more than group II. There was significant increase in platelets count in group II more than group I. There was significant increase in lipid profile (Cholesterol , Triglycerides , HDL and LDL) in group I more than group II. Significant increase in random blood glucose in group I more than group II. Significant increase in Oral glucose tolerance test ( Fasting blood glucose ,1hour after glucose load and 2 hour after glucose load ) in group I more than group II. Increase in Betatrophin percentage in group I compared to group II. No significant difference in age , gestational age , ALT level , AST level , albumin level , urea level or serum creatinine level. |