الفهرس 
Introduction & Aim of the workOnly 14 pages are availabe for public view
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Abstract
This study was conducted at the anesthesia and intensive care unit of El-Minia University Hospital for obstetrics and gynecology between February 2017 and February 2018. Sixty pregnant female patients, aged 18-42 years old, ASA I & II, 40 of them was pregnant female patients with mild preeclampsia and 20 of them was pregnant females with normal pregnancy were enrolled in this prospective randomized controlled study.
Patients were allocated into three equal groups 20 patients in each group; group A (preeclampsia group) received standard care and medications of PE. group B (preeclampsia with LMWH group) received the same care and medications of PE plus Enoxaparin sodium or Clexane (40 mg once daily by SC injection since diagnosis of PE). group C (control group) pregnant females with normal pregnancy received standard antenatal care.
The aim of this study was to evaluate the novel biomarker Neutrophil Gelatinase Associated Lipocalin (NGAL) as an early predictor of acute kidney injury (AKI) in patients with preeclampsia and also to determine whether the administration of Low Molecular weight Heparin (LMWH) has renal protective effect as determined by serum level of NGAL.
The following variables were recorded at the following time intervals (20, 30, 38 weeks gestation and 1, 15 days postpartum); systolic and diastolic blood pressure, number of cases with edema, proteinuria, CBC (Hb, TLC and platelets), liver function tests (ALT, AST and albumin), coagulation profile (PT, PC and INR), renal function tests (urea and serum creatinine), serum NGAL and correlation between them were recorded between the groups.
The results of this study revealed statistically significant reduction in systolic and diastolic blood pressure, number of edema cases in control group when compared with preeclampsia group and preeclampsia with LMWH group.
There was also statistically significant decrease as regard proteinuria, urea, serum creatinine level and serum NGAL level in preeclampsia with LMWH group and control group compared with preeclampsia group with positive correlation between serum creatinine and serum NGAL.
But there was no statistically significant difference between the three groups regarding CBC parameters, coagulation profile and liver function tests except serum albumin level which was statistically significant higher in preeclampsia with LMWH and control groups than preeclampsia group.