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Abstract Dissertation Title : some feed additives affecting rabbit production Objectives : The present study aims to investigating the impact of environmental pollution, represented in soil, irrigation water heavy metals, on the growth and production of Egyptian clover; a common fodder plant in Egypt. It also investigates the potential accumulation of cadmium in the berseem, which may cause health risk for animals and humans through the food chain. Also, the present study aimed to investigate the role of Vit E, Se or Zn on growth performance, some blood biochemical components, lipid peroxidation and antioxidant enzyme activities of serum, liver and kidney of growing rabbits fed diets contaminated by Cd Methods & Results : Animals and feeding system:At total of 120 growing APRI line rabbits (Egyptian line selected for litter weight at weaning according to Abou Khadiga et al., (2010) were divided randomly into six experimental groups of 20 rabbits each (10 males + 10 females) of 5 weeks of age, were used in this study. All rabbits were kept under the same managerial conditions. Basal experimental diet was formulated to cover all essential nutrient requirements for growing rabbit. The following six experimental groups were as follow: Treatment 1 : (control): fed basal diet containing 0.1 ppm cadmium (Cd) on DM basis.Treatment 2: fed basal diet contaminated with cadmium chloride (1.08 mg/kg diet) to provide Cd content of 0.96 ppm (as indicated from Cd content of berseem from contaminated areas at Kafr El-Sheikh Governorate)(contaminated diet).Treatment 3: fed contaminated diet plus 150 mg vit. E /kg diet. Treatment 4: fed contaminated diet plus 0.2 mg organic selenium / kg diet.Treatment 5: fed contaminated diet plus 100 mg organic zinc / kg diet.Treatment 6: fed contaminated diet plus 150 mg VE plus 0.2 mg Se plus 100 mg Zn /Kg diet. Parameters studied included growth performance and mortality rate of growing rabbits.Results obtained could be summarized as follow: 1- There were significant differences (P<0.05) in the concentration of cadmium among the different water types, where W3 recorded the highest concentration followed by W2, while W1 had the lowest concentrations. The concentration of Cd in W3 was higher than the normal level of cadmium. 2- There was significant differences (P<0.05) on cadmium contents in soil and berseem samples from the different locations, which reflects similar trend to their contents in water. Soil and berseem samples irrigated with W3 showed significantly (P<0.05) the highest cadmium contents followed by those irrigated with W2, while soil and berseem irrigated with W1 had the lowest contents Conclusion: from these results it could be concluded that using polluted drainage alone or mixed with Nile water in irrigation of agriculture land led to increasing the accumulation of cadmium in berseem causing possible hazardous effect in animal and human health. Contaminating of growing rabbit diets with cadmium revealed adverse effect on their productive performance, and mortality rate.The present study showed that vitamin E, Se , Zn alone or in combinations have protective effect on Cd-induced oxidative stress. This study therefore suggests that vitamin E, Se , Zn alone or combination may be a useful preventive agent against the effect of the studied cadmium at least partly due to its antioxidant properties. |