الفهرس 
Neuro-pathology of OCDOnly 14 pages are availabe for public view
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Abstract
Indtroduction: Obsessive-compulsive disorder (OCD) is a common, chronic condition that can have disabling effects on both genders throughout the patient’s lifespan. OCD can manifest with a wide range of clinical pictures. The one month prevalence of adult OCD is about 0.6% while the DSM-V 12 month prevalence of OCD in the United States is 1.2%, with a similar prevalence internationally (1.1%-1.8%). In DSM-III, DSM-III-R, and DSM-IV, obsessive–compulsive disorder (OCD) was classified as an anxiety disorder. In ICD-10, OCD is classified separately from the anxiety disorders, although within the same larger category as anxiety disorders (as one of the ‘‘neurotic, stress-related, and somatoform disorders’’)
Aims: The aims of this study are to: (1) Detect the frequency of occurrence of psychotic symptoms in OCD patients. (2) Analyze psychopathological relations between obsessive-compulsive and psychotic symptoms in a group of patients with OCD. (3) Study the differences in neuroimaging between OCD patients having psychotic symptoms and those without psychotic symptoms. (4) To verify if the obsessive subgroup with psychotic symptoms can be considered as a distinct OCD subtype.
Methodology: The study is a Cross-sectional comparative study conducted in Ain Shams university Hospital’s, psychiatry department between January 2015 and March 2017. During the study period subjects were collected from the patients attending the psychiatric outpatient clinic or inpatient and were found suffering from OCD. The sample consisted of approximately 121 OCD patients. 21 patients were excluded from the study. Thus, the clinical sample of this study consists of One Hundred OCD patients meeting inclusion and exclusion criteria.
Results: There was statistical significant difference between the volume of tracts ( anterior right & left thalamic, right & left corticospinal, right & left cingulate, right & left hippocampal, forceps major & minor, right & left inferior fronto occipital , right & left superior fasiculus, & right long fasiculus) between the OCD only group & OCD with psychotic features.
Conclusion: Patients suffering from OCD with psychotic symptoms have psychopathological and neuro-imaging aspects different from other OCD patients which makes them a distinct subgroup who needs special treatment plan. Taking into consideration, the need to add a specific specifier in the diagnostic classification which means that those group of patients need a specific plan of management