الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Diabetes is one of the most health problem globally with a serious impact on morbidity, mortality & health care resources. Cardiovascular diseases are the leading cause of death in individuals with type 1 diabetes. Aim: The purpose of this study was to evaluate the miRNA-133a expression in cardiac tissues of the diabetic rats and its relation to the cardiovascular complications. Methods: 20 male albino rats divided into group I (control) and group II (diabetic) 10 rats in each. Rats were made diabetic by intraperitoneal injection of streptozotocin (35mg/kg body weight). Physiological cardiovascular functions were assessed. Blood and cardiac tissue samples were taken from all rats for biochemical and histological studies. Quantitative RTPCR for miRNA-133 expression in cardiac tissues was performed Results: miR-133 expression was significantly increased in cardiac tissues of diabetic rats compared to control rats and was correlated to fasting blood glucose levels. Conclusion: the present study suggests that there is a complex relationship between miR-133 expression and the cardiac functions in diabetic rats which needs more exploration |