الفهرس 
I. DIABETES MELLITUSOnly 14 pages are availabe for public view
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Abstract
Background: Diabetes is one of the most health problem globally with
a serious impact on morbidity, mortality & health care resources.
Cardiovascular diseases are the leading cause of death in individuals
with type 1 diabetes.
Aim: The purpose of this study was to evaluate the miRNA-133a
expression in cardiac tissues of the diabetic rats and its relation to the
cardiovascular complications.
Methods: 20 male albino rats divided into group I (control) and group
II (diabetic)
10 rats in each. Rats were made diabetic by intraperitoneal injection of
streptozotocin (35mg/kg body weight). Physiological cardiovascular
functions were assessed. Blood and cardiac tissue samples were taken
from all rats for biochemical and histological studies. Quantitative RTPCR for miRNA-133 expression in cardiac tissues was performed
Results: miR-133 expression was significantly increased in cardiac
tissues of diabetic rats compared to control rats and was correlated to
fasting blood glucose levels.
Conclusion: the present study suggests that there is a complex
relationship between miR-133 expression and the cardiac functions in
diabetic rats which needs more exploration