الفهرس 
Uterine FibroidsOnly 14 pages are availabe for public view
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Abstract
The aim of our study is to compare between oxytocin and tranexamic acid as regard their safety and effectiveness on reducing perioperative blood loss and perioperative transfusion requirement during hysteroscopic myomectomy.
This study included 60 patients scheduled for hysteroscopic myomectomy allocated into 2 groups: group A: Patient received 10 mg/kg of tranexamic acid slowly intravenous after induction of anesthesia, group B: Patients received infusion of 10 IU of oxytocin at a rate of 400 mIU/min till the end of the procedure.
Preoperative and postoperative hemoglobin and hematocrit, need for blood transfusion, duration of operation, complications and medications’ side effects were recorded.
There was no statistically significant difference between 2 groups as regard age, parity, number of deliveries, number of abortions, size and grade of myomata.
In oxytocin group, the mean difference between preoperative and postoperative hemoglobin was -1.27 ± 0.84, while in the tranexamic acid group, it was -1.14 ± 0.83 with no significant difference (P= 0.558). In percentage, hemoglobin level was reduced by 11.06 % with SD ± 6.46 in oxytocin group, and by 10.21 % with SD ± 7.29 in tranexamic acid group with no significant difference (P= 0.636).
In oxytocin group, the mean difference between preoperative and postoperative hematocrit was -4.29 ± 2.86, while in the tranexamic acid group, it was -4.54 ± 2.80 with no significant difference (P= 0.730). Hematocrit level was reduced by 11.83 % with SD ± 7.34 in oxytocin group, and by 12.91 % with SD ± 7.58 in tranexamic acid group with no significant difference (P= 0.577).
No patient needed any blood component transfusion in both groups.
uterine perforation was the only operative complication occurred during the study that occurred in 3 cases in oxytocin group and none occurred in tranexamic acid group with no statistical significance (P= 0.192).
Nausea was the only medications’ adverse effect recorded during the study. It occurred in 3 cases of oxytocin group and in 2 cases of tranexamic acid group with no statistical difference between 2 groups (P= 0.643). No cases were reported to show thrombotic events within one week postoperative.
In conclusion, tranexamic acid and oxytocin are equally effective in reducing blood loss and transfusion requirements in hysteroscopic myomectomy with good safety profile. Both of them can be used according to the availability.