الفهرس 
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Abstract
The term NMSC is commonly used to refer to SCC and BCC; however, other types of NMSC, such as adnexal tumors and sarcomas, are less common and differ in their cell type, behavior, and epidemiologic features from NMSC. AK and BD are precursors of SCC and therefore described as NMSCs. They represent the most frequently observed malignancy amongst Caucasians. Goals in treating NMSC are, in order of importance, disease cure, preservation of function, & restoration of cosmesis. The available methods include surgical & medical ones. Photodynamic therapy is a recent therapeutic option that showed promising results in treatment of different types of NMSCs and is sometimes considered the treatment of choice in certain cases. PDT is based on using topical photosensitizer followed by broad-spectrum red radiation to induce necrosis of tumor cell by different mechanisms. Topical PDT is currently mainly used to treat superficial NMSCs in an increasing number of countries. Several guidelines have been published in the last two decades reporting the efficacy of PDT in treating NMSC. The aim of this thesis is to evaluate the efficacy of MB-PDT in the treatment of NMSC affected Egyptian patients through a prospective clinical trial with a twenty four months follow-up duration. Thirty three patients were enrolled in the study, twenty of them were suffering from nodular or ulcerative BCCs, eight from AK and five from BD, all patients were diagnosed clinically and confirmed histo- pathologically. All patients were diagnosed clinically and confirmed histopathologically & it took place during 2012-2016. Patients were selected from the outpatient clinics at The National Institute of Laser Enhanced Sciences & Cairo Hospital for Dermatology & Venereology (AlHaud AlMarsoud). Twenty seven completed the study, 17 suffering from BCC, 6 from AK and 4 from BD. and the others dropped due to various causes. In this study, we used topical LMB gel 0.2٪ irradiated by a total fluence of 48 J/cm2 from IPL source after 15 minutes of incubation, sessions were performed every two weeks until CR or for a maximum of six sessions. Of the seventeen patients suffering from BCC, Eleven of them (64.7٪) achieved CR, five (29.4٪) achieved PR & one achieved NR (5.9٪), of the eleven patients who achieved CR, three (33.3٪) reached this response after five sessions & eight of them (66.7٪) after six sessions, the mean number of sessions needed to achieve CR was 5. 7 +/- 0.47 sessions. Of the six AK patients who completed the study, four of them (66.7٪) achieved CR & two (33.3٪) achieved PR, the mean number of sessions needed to achieve CR was 5+/-0.7 sessions. Regarding the four BD patients who completed the study, two of them (50٪) achieved CR, one (25٪) achieved PR & one (25٪) showed NR, the mean number of sessions needed to achieve CR was 5.5+/-0.5 sessions. Most patients showed “Good” cosmetic outcome with minimally reported side effects in the form of mild pruritus & pain. At the sixth month follow-up visit, none of them showed any clinical signs of recurrence, and only one patient suffering from BD sohwed clinical recurrence at the last follow up visit, thus illustrating the efficacy of our proposed therapeutic regimen.