الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Asthma is a chronic inflammatory disorder of the airways characterized by an obstruction of airflow, which may be completely or partially reversed with or without specific therapy. Airway inflammation is associated with airway hyperreactivity or bronchial hyper responsiveness (BHR), which is defined as an inherent abnormal response of the airways to a wide variety of specific and non-specific stimuli resulting in increased airflow limitation .
Asthma is characterized by chronic inflammation of the airways, but the relevance of high-sensitivity assays for C-reactive protein (Hs-CRP), which are known to be a sensitive marker of low-grade systemic inflammation, has not been fully studied in asthma. The objective is to examine serum Hs-CRP levels in patients with asthma and their relationship to clinical characteristics and degree of airway inflammation. Also assessment .
The aim of the present study is to evaluate the serum Hs-CRP levels as marker of small airways inflammation and obstruction in asthmatic children through a case–controlled study and to assess its correlation to clinical (age, age of onset, sex, duration, severity, asthma control), laboratory (total serum IgE, absolute eosinophilic count) and pulmonary function parameters .
Ninety Eighty patients participated in the present cross-sectional case-controlled observational study in the period from June 2016 to Mai 2017 as well as 30age and sex-matched normal control children with no history of asthma or any other chronic diseases.Their ages ranged from 5 to 16 years with a mean 7.5 ± 3.36 and a male to female ratio 1.5:1 and all of them were regularly followed up in the pediatric clinic.
The study gave the following results:-
• There was a statistical significant relation between the HsCRP and the result of
the pulmonary function tests.
• There was no significant relation between the level of asthma severity and the levels of HsCRP, IgE, AEC .
• We found that spirometric parameters FEV1, FEF25-75 were significantly lower in high HS- CRP positive groups than HS-CRP negative groups reflecting small airways obstruction.