الفهرس 
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Abstract
The thesis involves the design and synthesis of some new tricyclic penciclovir (PCV) and hydroxybutylguanine (HBG) analogues (31-49) as well as anti-conformationally constrained pyrimidine nucleoside analogues (72-75 I and 72-75 II) with biological investigation for their anti-HSV and cytostatic activities. The thesis includes also attempts towards the synthesis of a novel bridged-purine acyclonucleoside analogue as a new HSV-1 TK inhibitor. Thus, the thesis is divided into 5 major parts. The first part is an introduction that includes an overview of HSV-1 infections and its therapeutic applications in cancer therapy. The second part describes the aims of this project.