الفهرس 
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Abstract
The purpose of the present study was to demonstrate the
effect of undifferentiated and differentiated MSCs in the
presence and absence of polylactic co-glycolic acid (PLGA)
nanofibers on carbon tetra-chloride (CCl4) induced
experimental mice chronic liver damage.
Forty-five local strain mice, weighing 25-30 gm, were used
in this work. chronic liver damage was induced by intraperitoneal
(I.P) CCl4 injection twice a week for eight weeks.
Five mice (Test control) were sacrificed after four weeks
and liver histopathological examination was done for
fibrosis confirmation.
The remaining mice were classified into four groups:
1- The control group (chronic liver failure-non-treated
group) in which, the mice subjected to a single intravenous
injection of 0.9% saline in the tail vein after 4 weeks post
CCl4 injection.
2- Undifferentiated HBMMSCs treated group in which, the
mice were injected with a single dose of 1 x 10 6 2-
undifferentiated HBMMSCs /mice in the tail vein, after the
4th week of CCl4 injection.
3- Differentiated HBMMSCs nano- treated group in which,
the mice were injected with a single dose of 1 x 10 6 3-
differentiated HBMMSCs nano- /mice in the tail vein, after
the 4th week of CCl4 injection.
4- Differentiated HBMMSCs nano+ treated group in which,
the mice were injected with a single dose of 1 x 10 6