الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 162 |  |  |
| | | from | 162 | | |
Abstract
Autism spectrum disorder (ASD) is a biologically based neurodevelopmental disorder characterized by impairments in two major domains: 1) deficits in social communication and social interaction and 2) restricted repetitive patterns of behavior, interests, and activities.. The reported incidence of ASD spectrum disorders has increased dramatically over the past two decades. It is a complex disease having genetic and environmental factors for example exposure to certain teratogens second trimester of pregnancy as valproate (VPA). studies have shown that genetic factors remain important. Added to this, early prenatal and postnatal exposure to environmental toxins causes the release of (ROS) Reactive Oxygen Species. which induces the pathological changes of ASD. The brain of autistic children shows several neuropathological abnormalities like the reduced number of Purkinje cells in the cerebellum, while Neurochemical, the most consistent finding in ASD is an increase in blood serotonin. Interestingly, serotonin is known to play an active role in brain development.
The gluten-free/casein-free diet is the most commonly used dietary intervention for children with ASD Up to 20% to 30% of families report trying this diet. It is based on the hypothesis that gluten and casein act like false neuropeptides in the brain. The hypothesis suggests there is the absorption of these peptides through a “leaky” intestinal membrane and that these compounds then cross the blood-brain barrier in children with ASD. This diet is used as a treatment for ASD in the absence of documented food allergy. On Arab societies depend on bakery products in their diet mainly hardly to find a food product free of casein and gluten and economically suitable for the social and economic situation of the pressure on autistic families. We have to mentation that the Ginkgo biloba, constituents possess potent central nervous system activity including enhancement of memory, concentration, mental alertness, and a decrease in mental fatigue. Many of these constituents produce memory boosting and mental altering effects also the Sage used for helping on reducing the oxidative stress and the free radical damages, infection, angiogenesis other studies reported the sage pharmacology and therapeutic effect some studies suggested helping in treating several diseases such as dementia, ASD, lupus, cancer, heart disorder, obesity, depression, and diabetes.
So, The aim of this Study is to investigate the effects of gluten-free casein free diet (GFCF) fortified with/out Sage (Salvia officinalis) or Ginkgo (Ginkgo Biloba) as a possible aid in the improvement of neurological, behavioral, neurochemical and histopathological changes associated with autism, to screen the nutritional, health situation, the economic impact on them and to find an economic alternative to the products free of casein and gluten.