الفهرس 
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Abstract
Azo compounds are widely used in industries. They had been detected
in different types of foodstuff, although they are not permitted in food.
The hepatotoxic effects of Sudan III with relation to oxidative stress
assessed in this study.
Eighteen rats were used in this study; they randomly divided into three
equal groups. The First group was given corn oil orally for consecutive
45 days and served as a control .The second and the third group were
orally administrated 12.5 and 25mg/kg b.w. (1/20 and1/40) of Sudan III,
respectively for 45 consecutive days. All the animals were sacrificed at
the end of exposure duration (on 46
th
day), blood and liver tissue
samples were taken for the biochemical and genotoxicity assays. Our
results revealed that oral administration of Sudan III for 45 consecutive
days resulted in significance(P0.05) increase in serum glucose, chol
,TG and HDL levels and AST,ALT activities both at low (12.5mg/kg )
and high (25 mg/kg )doses, compared to that in control untreated rats.
The total protein level was signifiFDQW 3) decreased at both doses
.however, there was no significant difference in serum albumin level
between treated groups. Significantly decrease in hepatic GSH content
,SOD and CAT activities were recorded in both low and high doses
groups .while MDA level was significant increased in the high doses
group .Hepatic DNA fragmentation with appearance of new bands was
recorded at both high and low doses of Sudan III.
Keywords: Azo compounds , Sudan III, Oxidative stress, Hepatotoxic.