الفهرس 
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Abstract
This study was carried out to investigate some of the internal parasitic diseases that affect Clariasgariepinus. 160 fish were collected randomly and seasonally from different sources in Ismailia governorate. Examined fish showed no pathognomonic clinical signs especially in low worm load. P.M. lesions were mostly paleness or congestion, presence of yellow white cysts on the accessory respiratory organ and enlargement of the liver with pin head spots. Total infestation rate was 75% in which the digenetic trematodes were the most prevalent parasite. The isolated parasites were Orientocredium sp., Astioremareniferum, Eumesenia sp. and EMC (Digenetic trematodes), Polyonchobotheriumclarias(Cestodes), Paracamallanuscyathopharynx, Procamallanuslaeviconchus(Nematodes), Acanthocephalan sp. and Henneguya sp. (protozoa). The infestation rate increased with the increase of the body weight and length, infestation in females were higher than males especially during spring and winter seasons. PCR used in identification of trematodes by using (ITS2) gave positive band at 539bp. Histopathological changes recorded were mostly degeneration, necrosis, sloughing of cells and infiltration.