الفهرس 
Introduction
Overview of Kidney FunctionOnly 14 pages are availabe for public view
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Abstract
Detect the effectiveness of vitamin C supplementation as antioxidant on the inflammatory status represented by CRP in patients with ESRD on hemodialysis.
Our study included 120 ESRD patients on regular hemodialysis for at least 6 months in (Assuit university hospital dialysis unit), Their ages ranged from age 30 to 69 years old with mean age ± SD (53.86 ± 7.98).
Duration of the study: one year (from June 2016 to June 2017).
Patients were classified into three groups:
• Intervention group: included 40 ESRD patients on hemodialysis (18 males and 22 females) and their ages ranged from 45 to 61 years old with mean ± SD (53.3±7.9), receiving 250 mg of vitamin C intravenously immediately at the end of each hemodialysis session three times a week for 8 weeks in a row.
• Control group 1: included 40 ESRD patients on hemodialysis (20 males and 20 females) and their ages ranged from 45 to 62 years old with mean ± SD (53.7±8.3), same term of placebo saline was injected.
• Control group2: included 40 ESRD patients on hemodialysis (20 males and 20 females) and their ages ranged from 47 to 62 years old with mean ± SD (54.7±7.8), with no intervention was performed.
We excluded all patients with history of renal transplantation for less than one year ago, using vitamin C or E or anti-inflammatory medications such as immunosuppressive agents, being infected by active infections or getting cancers and patients known to be smoker and/or habitual drinker.
The studied patients were subjected to the followings:
1. Complete history taking.
2. Thorough clinical examination.
3. Laboratory Investigation: CRP level at the start of the study and 8 weeks later.
The results showed a significant value to use vitamin C intravenously in ESRD patients to combat the chronic inflammatory state evidenced by CRP level.
Based on the results of this study, we can conclude that:
Intravenous venous vitamin C has a good role in improving the chronic inflammatory status in ESRD patients on hemodialysis.