الفهرس 
CONTENTSOnly 14 pages are availabe for public view
 |  | from | 139 |  |  |
| | | from | 139 | | |
Abstract
Conclusion In conclusion, because of the variety and complexities of the diseases that affect it, the breast is the most frequently biopsied organ so findings suggest the need for further efforts to educate practitioners and patients about the numerous advantages of MIBB for the evaluation of suspicious image detected breast lesions. Achieving a reduction in the rate of open surgical biopsy should remain a priority in health care delivery, which could eliminate many unnecessary operations in women In accordance with recent publications, we conclude that, especially at a time when expenditure is constantly reviewed, CNB is far superior to FNAC in the diagnostic approach of breast cancer and, especially in cases of doubt, it is preferable to proceed directly with CNB, which may also determine additional prognostic and predictive markers.Beside decreased sensitivity and specificity of FNAC in histopathological diagnosis of breast masses, it is also not suitable for the study of CSCs related genes due to poor RNA ratio isolated after flowcytometry.Results indicate that the aberrant gene expression of periostin in breast cancer tissue may induce significant biological effects. The present study found that AGBL2 was highly expressed in CSC and could be a potential biomarker for the lymph node metastasis and chemotherapy resistance of breast cancer tumors. The underlying genetic mechanism of periostin and AGBL2 in regulating the breast cancer CSC is still unclear and needs further investigation.