الفهرس 
General Introduction
RationaleOnly 14 pages are availabe for public view
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Abstract
In the presented thesis, a general introduction about Antigout drugs was presented. Also, six methods were developed and validated for the analysis of commonly prescribed Antigout drugs namely; febuxostat (FBX), colchicine (CLN), and probenecid (PRD). These methods are1.Facile micelle-enhanced spectrofluorimetric method for picogram level determination of febuxostat; application in tablets and in real human plasma. 2. Fluorimetric determination of febuxostat in dosage forms and in real human plasma via Förster resonance energy transfer3.Dual-wavelength thin-layer chromatographic–densitometric determination of febuxostat in combination with acetaminophen in synthetic mixture and in pharmaceutical formulations. 4.Innovative HPTLC method with fluorescence detection for assessment of febuxostat–montelukast combination and study of their protective effects against gouty arthritis. 5. New approach for simultaneous analysis of commonly used antigout drugs by HPLC/UV method; Application in Pharmaceutical and Biological Analysis 6. co-friendly Study for Analysis and Degradation of Colchicine by LC/MS Using Heterogeneous Fenton’s-Like Catalysis Coupled with Extraction of Its Biologically Active Metabolite.