الفهرس 
Introduction
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Abstract
The present work was carried out to reveal the pharmacokinetic profile of antibacterial drug cefquinome, fourth generation cephalosporins, in healthy rabbits following its intramuscular and intravenous administration at a single dose of 2mg/kg b.wt. and to investigate the impact of Pasteurella multocida infection on the pharmacokinetics of cefquinome. The study also evaluated its residue in tissues of treated rabbits after administration at therapeutic dose (2mg/kg intramuscularly for 3 consecutive days. The withdrawal time of cefquinome from rabbit tissues was also estimated. This work was carried out on forty six (46) New Zealand white rabbits weighing 2-2.5 kg. HPLC was used to measure cefquinome concentration in plasma and tissues of rabbits. Three experiments were performed as the following: The first experiment include 12 healthy rabbits which were used to determine the pharmacokinetics of cefquinome in healthy and P.multocida infected rabbits after IM administration. The following results were obtained: 1. In healthy rabbits, the maximum plasma concentration (C max) of cefquinome following its intramuscular administration was 6.93 ± 0.7 µg/mL achieved at time (T max) at 0.33 ± 0.05 h post-administration. The values of elimination half-life (T1/2λ) and area under the curve (AUC0-∞),) were 0.72 ± 0.06 h and 9.11 ± 1.44 h. µg/ml, respectively. Mean residence time (MRT) of cefquinome was 1.10 ± 0.02 h. Total body clearance of drug (CL_F) was 247.54 ± 38.49 mL/h/kg. 2. In Pasteurella multocida- infected rabbits the values of elimination half-life (T1/2 λz), area under the curve (AUC0-∞), area under the first moment curve (AUMC0-∞) and mean resident time (MRT0-∞) were significantly lower than in healthy rabbits. Total body clearance of drug (CL_F) was significantly higher in infected than in healthy rabbits. The 2nd experiment include 10 rabbits were used to determine pharmacokinetics of cefquinome in healthy rabbits following IV administration and The following result was obtained: After a single intravenous administration of cefquinome sulphate at a dose rate of 2mg/kg, The values of elimination half-life (T1/2λ), area under the curve (AUC0-∞), Mean residence time (MRT), and Total body clearance of drug (CL_F) were 0.52 ± 0.05 h, 9.13 ± 0.63 h. µg/ml, 0.75 ± 0.06 h and 239.25 ± 14.61ml/h/kg, respectively. The 3rd experiment include 24 (twenty four rabbits) which were used to study the depletion of cefquinome from rabbit tissues. The concentrations of cefquinome resdiues in kidney and liver from rabbits IM administered 3 times at a dose of 2 mg/kg of body weight with 24-h intervals were below the acceptable EUMRL at 10 and 2 days of withdrawal time, respectively. One day withdrawal time for the muscle was suggested.