الفهرس 
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Abstract
Type 1diabetes mellitus is one of the most common diseases in child hood, its incidence has been rising globally and about 90,000 new cases diagnosed yearly. Microvascular complications of Diabetes including retinopathy, nephropathy and neuropathy are serious complications in children and adolescents with T1DM. DN is considered one of the major causes of morbidity and mortality in young adults with T1DM. End stage renal failure may develop eventually and necessitates renal replacement therapy or renal transplantation. So, early detection of DN and early management of high blood pressure play a vital role in delaying or even preventing ESRF in children and adults with DM . Diabetic researches hase been focusing on the genetic susitability of diabetic nephropathy as significant numbers of patients devolop nephropathy regardeless of glycemic control or other khnown risk factors. IL10 level has avital role in regulating immune system and envolved in pathogenesis of many diseases including DN. IL 10 polymorphisms have been proven to affect its level and function. So, our research and many others have been trying to identify polymorphisms that have significant association with kidney impairment in diabetic patients. We studied IL-10 SNP rs 1518111 polymorphism in 70 patients with type 1DM (37 with DN ,33 without DN) and 30 healthy controls. There was a significant correlation between AA genotype and A allele of this polymorphism and the risk of diabetic nephropathy. Also, longer duration of diabetes, higher doses of insulin, poor glycemic control are associated with development of DN. Elevated systolic BP and lower GFR were found in our patients with DN . ConclusionThe AA genotype and A allele of IL-10 SNP rs 1518111 is significantly correlated with susceptibility to diabetic nephropathy in patients with type 1 DM. Further studied are needed on larger sample size to confirm our results. Recommendation We recommend analysis of IL-10 SNP rs 1518111 , if available, in newly diagnosed patients with DM and those with AA genotype will need a strict glycemic control and close follow up of BP , proteinuria and kidney function tests. Further studies with larger sample size and different ethnic groups are needed to highlight the role of our gene polymorphism and other polymorphisms in the risk of DN development.