الفهرس 
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Abstract
This prospective case control study was carried out on 45 male subjects who were: smokers with COPD, smokers without chest diseases and controls without cardiopulmonary diseases attending the Chest Department Menoufia University. They were classified in to 3 groups:
group I: A group of 20 smokers with chronic obstructive pulmonary disease.
group II: A group of 15 smokers with no chronic obstructive pulmonary disease or other cardiopulmonary diseases.
group III: A group of 10 healthy non-smokers, included as a control group.
After having approval of Medical ethics Comittee and an informed consent; all patients underwent the following:
Full history taking, clinical examination, routine laboratory investigations, measurement of serum level of uric acid [sUA] and serum creatinine level, chest X ray and post bronchodilators pulmonary function tests (FEV1, FVC, FEV1/FVC and FEF50%).
This study showed that; sUA was statistically significantly higher in both groups I and II than in group III. SUA/creatinine ratio was statistically significantly higher in group Ithan in both groups II and III. It was also statistically significantly higher in group II than in group III .
SUA showed statistically significant positive correlations in COPD patients with smoking index, serum creatinine level, COPD grades and PaCo2 and negative correlations with FEV1/FVC, PaO2 and O2 saturation.
In non COPD smokers (group II), there were statistically significant positive correlations between sUA level and sUA /creatinine ratio and serum creatinine level and negative correlations with FVC%, FEV1 and FEF 50%.
SUA / serum creatinine ratio showed statistically significant positive correlations in COPD group with smoking index, serum creatinine level and negative correlation with FEV1.
In non COPD smokers sUA / serum creatinine ratio was statistically significantly negatively correlated with FEV1/FVC.
The ROC analysis indicated that; sUA/creatinine ratios can be more useful than sUA levels alone in the diagnosis of severity of COPD with higher sensitivity and specificity .
These results emphasize the effect of cigarette smoking and chronic obstructive airway diseases on sUA and sUA /creatinine ratio.