الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
This work was planned to diagnose and differentiate different causes of scour in calves and also to evaluate some pharmacological effects of cefquinome on blood picture, liver and kidney functions and body weight in calves. Ten Holstein calves (3-15 days old) infected by E. coli in a special dairy farm at Damietta Governorate were injected intramuscularly in the thigh muscle by cefquinome and the dose was (2mg/ kg body weight) for 3 successive days and other ten Holstein healthy calves were kept as control group. Two blood samples (the first sample for hematological studies and the second sample for serological studies) were collected from each experimental animal at zero day, 3rd, 7th and 14th day. 1-Blood samples were collected on Wassermann tube containing EDTA and collected from jugular vein of all calves for hematological parameters studies (erythrocytic count, leukocytic count, Hb, PCV, MCV, MCH, MCHC and thrombocyte count.) 2- The second blood samples were collected in Wassermann tube without anticoagulant from jugular veins of all calves and allowed to clot at room temperature .the serum was separated by centrifugation the sera were collected in Eppindorff tubes and kept frozen at -20˚ c for biochemical studies (total proteins, albumin, ALT, AST, ALT, Urea and creatinine). The present study revealed a significant decrease in total erythrocytic count, hemoglobin content and PCV in cefquinome treated group at zero, 3rd, 7th and 14th days post treatment compared to the control group. The results showed a significant decrease in mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration in cefquinome treated group at zero, 3rd, 7th and 14th days post treatment compared to the control group. The present data mirrored a significant increase in total leukocytic count in cefquinome treated group at zero, 3rd, 7th and 14th days post treatment compared to the control group. The recorded results showed a significant decrease in neutrophil % in cefquinome treated groups at zero and 14th days post treatment compared to the control group. These data showed a significant increase in monocyte percent of cefquinome treated group at 7th and 14th days post treatment compared to the control group. Our work reflected a significant decrease in thrombocyte percent of cefquinome treated group at 3rd day post treatment compared to the control group. Our data detected a significant decrease in total protein in cefquinome treated group at 14th day post treatment compared to the control group. Also the work detected a significant decrease in albumin in cefquinome treated group at 14th day post treatment compared to the control group. While significant increase in globulin was detected in cefquinome treated group at zero and 3rd days post treatment compared to the control group. Moreover, the results showed a significant increase in aspartate transaminase (AST) and alkaline phosphatase (ALP) levels in cefquinome treated group at zero, 3rd, 7th and 14th days post treatment compared to control group. Not only that but also there was a significant increase in urea in cefquinome treated group at zero, 7th and 14th days post treatment compared to the control group. Also the work detected a significant increase in creatinine in cefquinome treated group at zero, 3rd, 7th and 14th days post treatment compared to the control group.