الفهرس 
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Abstract
A total of fifteen adult clinically healthy Mongrel dogs had been selected in this study, ranged from 1-4 years old and their body weight from 15-25 kg. The study was carried out for experimental induction of diabetes mellitus in dogs to investigate the clinical findings and evaluation of the biochemical parameters as well as trials of novel treatment using (insulin and omega-3combination) and (insulin and liraglutide combination) compared to that of normal control. All animals under experimentation were divided into 3 groups each group consisted of five dogs, the first group contained normal healthy dogs served as non-diabetic control group (group 1), the second group (group 2) injected with (Alloxan) for experimental induction of Diabetes Mellitus and was treated with a combination of (insulin and Liraglutide). The third group (group 3) was injected by Alloxan for experimental induction of Diabetes Mellitus and treated with a combination of (insulin and omega-3). Regarding the clinical findings in diabetic dogs, the physical examination results revealed polyuria, polydipsia, increased appetite with weight loss were the most prominent signs in diabetic dogs. Lipid profile results in the second group revealed an elevation in the cholesterol and triglycerides as well as low density lipoprotein (LDL), while there was a significant reduction in the high density lipoprotein (HDL).In the third group the results showed an improvement in lowering the levels of cholesterol, triglycerides and low density lipoprotein (LDL), while the level of high density lipoprotein (HDL) was elevated. Concerning the serum biochemical tests, fasting serum glucose level, serum insulin, Plasma glucagon level and Plasma (GLP-1) levels our findings revealed significant elevation in the third group. On other hand the second group showed an improvement as there was a significant decrease in their levels compared with the second group