الفهرس 
Chronic hemodialysisOnly 14 pages are availabe for public view
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Abstract
Cardiovascular disease is the leading cause of mortality and morbidity in patients with chronic kidney disease. Also cardiovascular calcification is a risk factor for the pathogenesis of cardiovascular disease and mortality in dialysis patients.
Meanwhile some clinical studies suggested anticalcific properties of magnesium, and tried to study the relation between serum magnesium levels, vascular calcification and cardiovascular mortality among patients with end-stage renal disease.
On the other hand, some studies suggested that hypermagnesemia may inhibits parathyroid hormone secretion, and this may be risk factor for vascular calcification, left ventricular hypertrophy and more mortality in end-stage renal disease patients.
Accordingly, the present study was designed to examine the possible relation between serum magnesium level, PTH, and cardiovascular calcification in chronic hemodialysis patients.
This study was conducted on fifty patients, on more than 3 months duration of regular conventional hemodialysis –in hemodialysis Unit of Internal Medicine department in – Menoufyia University – and Benha Teaching Hospitals - EGYPT. Patients with rheumatic or congenital heart disease, and patients talking drugs that may affect the serum magnesium levels were excluded.
All patients were examined clinically and were subjected to complete blood count, kidney function tests and serum electrolytes, iPTH, serum albumen, lipid profile, HBA1C %, random and glycated blood glucose, serum magnesium level, carotid Doppler, transthoracic echocardiography and lateral abdominal X-Ray.
Patients were divided into 3 groups according to serum magnesium level (low, normal, or high magnesium level).
Results of our study demonstrated that:
Cardiovascular calcification is common in studied patients as most patients(56%) had cardiac valve calcification, and about third of patients(32%) with abdominal aortic calcification, while about fourth(22%) of the studied patients had increased common carotid intimal-medial thickness.
Serum magnesium level had significantly inverse relation with cardiac valve calcification detected by transthorathic echocardiography, and with vascular calcification represented by abdominal aortic calcification.
Patients with higher PTH levels were significantly associated with cardiac valve calcification and abdominal aortic calcification. Also it had significant association with lower serum magnesium levels in the studied patients.
Smoking could be risk factor to hypomagnesemia in regular hemodialysis patients, as it significantly associated with lower magnesium levels in our studied patients.
Also, patients with hyperlipidemia represented by higher LDL levels were more associated with lower magnesium levels.
Our study did not found significant relation between the serum magnesium levels and CCIMT, and other clinical or laboratory investigations.