الفهرس 
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Abstract
The present study was carried out to evaluate the potential usefulness of aqueous extract of chamomile (Matricaria chamomilla), oregano (Origanum majorana) and fennel (Foeniculum vulgare) on LPS/D-gal induced toxicity. The severity of induced hepatotoxicity and nephrotoxicity in the different groups of albino rats were studied in relation to the level of antioxidants, antioxidant enzymes and abnormalities during the oxidative stress. One hundred adult male albino rats (weighing 120-140 g) were allocated into eight groups. At the end of the each experimental period, the rats were sacrificed. Blood,liver, kidney and spleen samples were immediately collected.The results indicated that oral administration of 400 mg Matricaria chamomilla, 250 mg Origanum majorana or 250 mg Foeniculum vulgare extracts to LPS/D-gal toxificated rats daily for 3 weeks significantly decreased the elevated serum levels of liver enzymes (AST, ALT, ALP and GGT) and decreased the elevated level of lipid peroxidation in liver and kidney tissues when compared to the corresponding LPS/Dgaltoxificated groups. Levels of antioxidant enzymes Reduced glutathione and Catalase in liver and kidney tissues were significantly increased as compared to the LPS/Dgaltoxificated groups. Also, modulation of the expression of TNF alfa, IL-6, IL-4 and IL-10 induced by LPS/D-gal and maintains the functional integrity of hepatic and renal cells. The Histopathological studies of liver and kidney tissues showed improvement of histological structure of liver and kidney when compared to the corresponding LPS/D-gal toxificated groups. from our results, it could be concluded that the aqueous extracts of chamomile (Matricaria chamomilla) and oregano (Origanum majorana) andfennel (Foeniculum vulgare) exert beneficial modulatory effects in treatment of LPS/D-gal induced toxicity.