الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 107 |  |  |
| | | from | 107 | | |
Abstract
Amblyopia can be defined as ―reduced best corrected visual acuity (BCVA) in one or both eyes caused by abnormal visual experience during visual development‖. It may be caused by sensory deprivation, image blur from refractive errors, strabismus, or combination of these factors.
Amblyopia usually associated with changes in the distribution of ocular dominance patterns in the visual cortex, cell shrinkage in the lateral geniculate body, and optic nerve hypoplasia.
Retinal nerve fiber layer (RNFL) is considered a very sensitive indicator of early glaucoma preceding other structural and functional changes of glaucomatous damage.
The study aimed to compare retinal nerve fiber layer (RNFL) thickness, macular thickness and ganglion cell layer thickness between amblyopic and fellow eyes using spectral domain optical coherence tomography (SD-OCT).
Seventy six patients were included in the study (32 males and 44 females; age range 18–40 years; mean age 27.21 ± 8.25 years), detailed medical history of all patients was obtained, all underwent detailed ophthalmologic and fundoscopic examination by slit lamp biomicroscopy, visual acuity by Landolt’s chart, cycloplegic refraction, ocular alignment, applanation tonometry, OCT imaging by SD-OCT (Cirrus-5000 OCT, Germany).
By OCT imaging, there was no significant difference between the amblyopic and fellow eyes regarding central macular thickness (CMT), average macular thickness or ganglion cell complex (GCC).
By further secondary analysis aiming to compare subgroups according to refractive status, only RNFL thickness ― main RNFLT ‖ was significantly lower in amblyopic eyes compared to fellow eyes in myopic amblyopic subgroup only, Other OCT values comparison results were not significant in other amblyopic eyes versus fellow eyes in different subgroups.
We concluded that no significant relation between amblyopia and OCT parameters, however OCT revealed significant reduction in mean retinal nerve fiber layer thickness (RNFLT) in myopic amblyopic eyes only versus their fellow eyes, axial length may be more influential than amblyopia.