الفهرس 
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Abstract
Introduction :The wide use of antibacterial drugs in veterinary field, but due to prolonged usage and the ignorance of drugs withdrawal periods leads to the appearance of their residues in milk that have bad effect either on public health and economic losses. Materials and methods :A total of 200 raw milk samples were collected from small dairy farms, street peddlers and dairy shops in Mansoura by using screening method Bacillus Subtilis diffusion assay positive result exposed to HPLC method for both oxytetracycline and sulfamethazine samples that exceed to maximum residues limit exposed to boiling to detect its effect on their existence. Results :Out of 200 sample 30 positive for presence of antibiotics then samples exposed to HPLC the presence of oxytetracycline was 8.5% and for sulfamethazine was 4% after boiling for 2 min and 5 min oxytetracycline and sulfamethazine decreased by30.5%, 54.1% and9.5%,1.7% respectively. Conclusion:During boiling of milk , there was a partial reduction in antibiotic residues but not completely eliminated , the residues of oxytetracycline showed to be less thermostable so if milk kept at that temperature for at least two minutes would allow a variable decrease in its amount but not a complete elimination ,while sulfamethazine residues were very stable during a process of boiling.