الفهرس 
I. INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
This study was conducted on 50 patients with an incidentally
discovered diffuse fatty liver by US. They were fifty asymptomatic
patients (17 males, and 33 females). The overall mean age was 53.5 ±
9.9years (range, 30 – 73 years).
The aim of this work was to study the role of IP-OP magnetic
resonance imaging in quantification of liver fat content in patients with
NAFLD.
All Patients in this study were subjected to thorough history
taking including age, sex and medical history, full clinical examination
including vital signs, general examination, measurements of weight,
standing height and BMI, real time abdominal US and IP-OP MR
imaging.
Non alcoholic fatty liver disease was found to be slightly more
common in postmenopausal women. The possibility that female
hormones protect against NAFLD has been postulated and supported by
evidence that NAFLD was twice as common in postmenopausal women
as in premenopausal women. Those who receive hormone replacement
therapy were significantly less likely to have NAFLD compared to
women who did not.
Hepatic steatosis may be influenced by visceral fat accumulation
regardless of body mass index. Visceral fat accumulation appears to be a
significant risk for the development of NAFLD.
In-phase and out-of-phase MR images provide useful information
about the LFC. Our findings showed that a simple method can be used to
determine if LFC is within the normal range. Measurements from IP-OP
images provide a more reliable approximation of the true LFC than does subjective image interpretation, even if the interpretation is performed by
an experienced radiologist. The advantages of this method are that it can
be a guideline for less experienced radiologists and it is valid throughout
the wide range of LFCs often observed in patients with type 2 diabetes
mellitus and NAFLD.
Increased use of IP-OP imaging to assess LFC has the potential to
promote early detection of NAFLD and to potentially improve treatment
evaluation.
Thus, finally our recommendations are:
1. Magnetic resonance IP-OP is a non-invasive valuable technique for
the estimation of hepatic steatosis better than liver biopsy.
2. Future research in which 1H MR spectroscopy is compared with
signal intensity changes on IP-OP images in patients with severe liver
disease is needed.
3. Further studies with larger sample size and longer time of follow-up
by MRI IP-OP are recommended for patients with hepatic steatosis.