الفهرس 
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Abstract
Preeclampsia is a multisystem disorder of unknown cause, with a presentation from mildly elevated blood pressure to severe hypertension and multiorgan dysfunction. The incidence of preeclampsia ranges from 2 to 7 percent in healthy nulliparous women and 3 to 4 percent in multiparous ones.
Identification of women who are high risk for PE could potentially improve outcome of pregnancy for early intensive maternal and fetal monitoring in such patients will lead to an earlier diagnosis of the clinical signs of the disease. Effective screening for pre-eclampsia can be achieved through a combination of uterine artery doppler and maternal biochemical variables.
The pregnancy-associated vascular changes are largely due to circulating angiogenic factors as placental growth factors (PlGF), which are involved in normal trophoblastic proliferation and the new formation of blood vessels from endothelial cells. The abnormal implantation may related to the maternal immune system’s response to the placenta, and lack of established immunological tolerance in pregnancy. Endothelial dysfunction is responsable of symptoms and sign of preeclampsia.
Abnormal spiral artery remodelling was first postulated over five decades ago related to placental hypoxia, increase in oxidative stress and aberrant maternal systemic inflammatory responses and has been accepted as leading causes of pre-eclampsia.
Vitamin D is consider one of oxidative stress that may be risk factor to preeclampsia.and the aim of our study was done to asses the relation between vitamin D and preeclapsia.
The study was carried out on 90 pregnant patients attented antenatal unit and intensive care unit in El Shatby Maternity university hospital.
The patients in this study were divided into three groups:group I: thirty normaltensive pregnant women,groupII: thirty mild preeclampsia pregnant women and groupIII: thirty sever preeclampsia pregnant women.
Full history taking , complete general examination,obstatric ultrasound examination , blood sampling , urine analysis and measurment of maternal vit D level by chemiluminescence.
According to the stastic result of our study ;
There was a statistical significant difference between the study group as regard to gestational age, platelets count, liver functions , 24 hours collected protein in urine and intrauterine growth restriction.
There was no statistical significant difference between study groups according to ; maternal age and haemoglobin level.
There was no statistical significant difference between study groups according to serum level of vitamin D.
There was statistical significant difference between haptoglopin and AST ,ALT and intrauterine growth retardation.but no ststistic significant between haptoglopin and level of level of vitamin D