الفهرس 
Introduction
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Abstract
This study was performed in Veterinary Pharmacology Dept. Tokyo University of Agriculture and Technology. The experiment was performed to investigate the pharmacokinetic profile of sulfaquinoxaline and sulfamonomethoxine in healthy rabbits following its oral and intravenous administration of a single dose of 20mg/kg b.wt for each drug using a crossover design with at least a 3-week washout period between each route. . This work was carried out on ten rabbits weighing 2.5" ~ "3.5 kg. Blood samples (1 ml for each sample) were collected from the right ear vein immediately prior to the treatment and 0.08, 0.25, 0.5, 1, 2, 4, 6, 12 and 24 h after dosing for SQ. While in SMM collect prior to the treatment and 0.08, 0.5, 1, 3, 5 and 8 h after dosing. The samples were placed in tubes containing EDTA and centrifuged at 2,000 g for 10 min and the plasma samples were stored at –20°C until analysis. SQ concentrations were determined in the plasma by using high performance liquid chromatography (HPLC) with UV-detection. After a single IV injection of SQ (20mg/ kg). Distribution half – life (t0.5(α)) equaled to 0.40 h. The volume of distribution (V1c) was 0.09 ml/kg. The elimination half – life (t0.5(β)) value of 6.61 h and cleared (CL) from the body at a rate of 0.02 ml/kg/h. The peak plasma concentration (Cmax) was 222.81 µg/ ml. Sulfaquinoxaline after oral administration elimination half-life (t0.5(β)) of 8.56h, absorption half-life (t0.5(ab)) was 0.33h and the volume of distribution (V/F) was 0.10 ml/kg. Sulfaquinoxaline was cleared from the body at a rate of 0.01 ml/kg/h. The peak plasma concentration (Cmax) was 222.81 µg/ ml and obtained at (Tmax) of 0.05 h post injection. The pharmacokinetic parameters of SMM after IV administration were recorded. The half – life (t0.5(α)) equaled to 0.33 h. The volume of distribution of (V1c) was 0.15 ml/kg.. SMM was eliminated with half – life (t0.5(β)) value of 2.54 h and cleared from the body (CL) at a rate of 0.05 ml/kg/h. The peak plasma concentration (Cmax) was 132.72 µg/ ml. The area under curve (AUC) was 376.60 µg/ ml/h. The obtained results after PO administration showed that absorption half-life (t0.5 (ab)) was 0.02 h. elimination half-life (t0.5el) of 1.99h and volume of distribution (V/F) was 0.17 ml/kg. SMM was cleared from the body (CL) at a rate of 0.06 ml/kg/h. The peak plasma concentration (Cmax) was 114.06 µg/ ml and obtained at (Tmax) of 0.12 h post injection.