الفهرس 
Psoriasisيوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Background: Psoriasis is a chronic, autoimmune, and inflammatory disease of unknown etiology. The association of the novel adipokines visfatin and omentin-1 with psoriasis is still obscure. Data concerning other inflammatory diseases suggest a possible role of these adipokines in the pathophysiology of psoriasis.
Objective: The aim of the current study is to estimate serum and tissue levels of visfatin, omentin-1 and lipid profile in patients with psoriasis compared to healthy controls, and their relation to disease severity to investigate their possible role in pathogenesis of psoriasis.
Methods: A cross sectional case-control study carried out on 28 patients with plaque-type psoriasis and 28 healthy controls, BMI was calculated, serum and tissue visfatin, omentin-1 levels and lipid profile were measured by using the ELISA technique.
Results: Serum and tissue levels of visfatin in psoriasis group were significantly higher than controls (p-value=0.001, 0.04 respectively). There was a significant positive correlation between serum and tissue visfatin levels and PASI score (r = 0.53, p = 0.003 and r = 0.39, p = 0.001. Serum omentin-1 level was significally lower in patients group than controls (p-value = 0.017). Also, LDL was significally higher (p-value = 0.029), HDL was significally lower in psoriasis group than controls (p-value = 0.001), there was no sign of correlation between each of visfatin and omentin-1 levels and BMI.
Conclusion: Psoriasis patients have higher serum and tissue visfatin and lower serum omentin-1 in comparison to controls, which is not correlated with BMI. High visfatin levels were positively correlated with disease severity which reveal a possible role of visfatin, omentin-1 and lipid profile in pathogenesis of psoriasis and potential cardiovascular comorbidity.
Key words: Psoriasis, visfatin, omentin-1, lipid profile.