الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
People often seek care from multiple sources outside the formal traditional health care system. One of these sources is the use of Complementary and Alternative Medicine (CAM) including herbal plants. Medicinal plants are played an important role in modern health care and also prevention or enhancement of numerous diseases. Researchers around the world currently focus on natural products to treat diabetes mellitus such as cinnamon due to increased wide range of biological activity. Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Many strategies were explained to decrease or prevent the complications ofdiabetes mellitus and some of this strategies are based on remedied by active constituent of plant origin .one of this plants is cinnamon extract which is considered to be a natural insulin sensitizer and has been studied all over the world. Other strategies are used as drug administration. One of this drugs is gliclazide act as an oral hypoglycemic agent. Our present study aimed to estimate the effect of orally administration of aqueous extract of cinnamon and gliclazide suspension in protection from diabetes mellitus through detection of some selective hematological, biochemical parameters and also oxidative stress marker and anti-oxidant enzymes through evaluate the hepatic MDA SOD, CAT and GSH. This study was conducted on 140 rats (1-2 month old). After 15 days of acclimatization in cages condition, Rats were divided into equal seven groups as follow: GP-I served as control (give normal saline), GP-II treated with streptozotocin (55 mg/kg Bw,I/P as a single dose), GP-III treated with cinnamon extract (300 mg/kg BW daily orally for 4 weeks), GP-IV treated with gliclazide suspension (10 mg/kg Bw daily orally for 4 weeks), GP-V treated with STZ (55 mg/kg BW) and cinnamon extract (300 mg/kg BW orally/day), GP-VI treated with STZ (55 mg/kg BW) and gliclazide suspension (10 mg/kg BW orally/day) and GP-VII treated with STZ (55 mg/kg BW), cinnamon extract (300 mg/kg BW orally/day) and gliclazide suspension (10 mg/kg BW orally/ day). The treatment duration is for 4 successive weeks for all groups daily. After 2nd and 4th weeks of treatment, 10 rats were picked up randomly from each group and blood samples were collected from medial canthus of the eye to investigate some hematological parameters and investigate serum biochemistry, then rats were scarified and 0.5 gram of liver tissue was collected from each rat for preparation of liver homogenate for evaluation of antioxidant and oxidative stress and 1 gram of pancreatic , hepatic and renal tissues were collected for histopathological examination.