الفهرس 
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Abstract
A. baumannii has been recognized as an opportunistic pathogen and one of the leading caused of nosocomial infections including urinary tract infections, respiratory tract infections, bacteremia and surgical site infections. Therefore, the study aims to evaluate the prevalence of resistance to different classes of antimicrobial agents among A. baumannii isolates collected from different clinical sources in Mansoura University Hospitals, Egypt. Moreover, the study aims to investigate the chief mechanisms underlying resistance to different beta-lactam antibiotics. In the present study, 200 specimens of Gram negative bacterial were collected from different clinical sources, 50 out of 200 specimens identified as A. baumannii isolates including blood [21(42%)], sputum [15(30%)] and urine [14(28%)] from Mansoura University Hospitals (MUH). All A. baumannii isolates were resistant to these antibiotics cefoxitin, cefotaxime, cefepime, imipenem, azetronam and sulfamethoxazole / trimethoprim. While, all isolates were sensitive to polymyxin B and colistin. In addition, the tests isolates showed different degree of resistant from 70% to 98% for pipracillin / tazobactam, ceftazidime, meropenem, ampicillin / sulbactam, gentamicin, amikacin, ciprofloxacin, levofloxacin. It became resistant to the majority of commercially available antimicrobial agents. A polymyxin and Clostin are the last resort for treatment in patients with high suspicion of CR A. baumannii. This study underlies the importance of accurate identification and reporting of Acinitobacter spp. to prevent the emergence of epidemic of resistant A. baumannii circulating in hospitals.