الفهرس 
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Abstract
Hypocholesterolemia has been known be a significant prognostic indicator of increased morbidity and mortality during the course of pathological conditions.
Aim of the study:
To evaluate the difference between serum cholesterol and triglyceride level in septic and non septic patients in the surgical intensive care Unit (SICU) and to find correlation between the level of serum cholesterol and triglyceride and both APACHE II and qSOFA score.
Methods:
The study included 95 patients of both sex who were admitted to the SICU and randomly assigned into two groups, septic patients ( group S, n=50) or non-septic patients (NS, n=45) .The following data were recorded (Age, sex, the cause of SICU admission, number of patients needed administration of vasoactive drugs, length of ICU stay, 28-day mortality, days on mechanical ventilation, (APACHE II) scores,(qSOFA) scores,serum cholesterol, and triglyceride on days 0 (SICU admission) and on 1st, 3rd, 7th,10th and 14 th days.
Results:
APACHE II score was statistically significantly higher in the septic group(S) [32 (24-48)] than the non septic group (NS)[8.5 (2-35)], (P value < 0.001).
qSOFA score was statistically significantly higher in septic group(S) [2 (2-3)] than the non septic group(NS) [1 (0-3],(P value < 0.001).
28- days mortality was statistically significantly higher in the septic group(S):88% (44 patients) versus 17.7% (8 patients)in the non septic group (NS): , (P value < 0.001).
Length of SICU stay was statistically significantly higher in the septic group(S) (13.9 ± 9.3) than in the non septic group(NS) (4.4 ± 1.9); (P value < 0.001) .
Cholesterol level (mg/dl):
Day 0: was statistically significantly lower in the septic group (S) (119.4 ± 29.33 ) than in the nonseptic group (NS) (131.2 ± 35.37) ( P value = 0.037).
Day 1: was statistically significantly lower in the septic group(S) (103.6 ± 29.19 ) than in the nonseptic group (NS) 123.56 ± 36.5( P-value < 0.001) .
Day 3: was statistically significantly lower in the septic group(S) (80.7 ± 26.87 ) than in the nonseptic group (NS) 124.84 ± 32.4( P-value < 0.001).
Triglyceride level (mg/dl):
Day 1: was statistically significantly higher in the septic group )S) (151.5 ± 54.79 ) than the non-septic group(NS) (112.14 ± 33.02) ( P value < 0.001) .
Day 3 : was statistically significant higher in the septic group )S) (185.1 ± 43.2) than the non-septic group (NS) (113.5± 39.56) (P value < 0.001).
Conclusion:
Cholesterol levels decreased markedly, and triglyceride levels increased in patients with sepsis compared to non-septic patients, and there was a significant difference between septic and nonseptic patients for cholesterol and triglyceride levels. The septic patients who had a low level of cholesterol and high level of triglyceride had a higher rate of mortality than the nonseptic patients, in the septic patients there was increasing in length of ICU stay, administration of vasoactive drugs, days on mechanical ventilation, higher qSOFA, and APACHE II scores compared to non-septic patients.
Key-words: Cholesterol ,Triglyceride , Sepsis ,Non Septic patient
Trial registration number : NCT03359369.