الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
ED is a common serious problem affecting the quality of life for sexually active men across all age groups. Its etiology is multifactorial, risk factors include age, DM, smoking and CVD. ED is 2-3 folds higher in diabetic men compared to non-diabetic men. Understanding the mechanisms of DM-induced ED is important for early diagnosis and prevention. There is a growing interest about the role of endothelial dysfunction in diabetes and the development of ED, endothelial dysfunction is associated with defects in eNOS expression and activity, changes in the production and/or action of hormones, growth factors and cytokines, increased oxidative stress and increased generation and activity of opposing vasoconstrictors. Biomarkers may be used as indicators of early disease and play a role in the prevention of ED.
This study aimed at searching the diagnostic ability of sVEGF in early detection of ED in diabetic patients.
A prospective cross-sectional study was conducted on diabetic patients with ED selected from attendees of the Mansoura University outpatient clinics. They were compared to age matched diabetic patients without ED, non-diabetic patients with ED and healthy control groups. All participants were subjected to full medical history, complete clinical examination, and laboratory investigations with collecting samples for serum sVEGF. This study revealed that serum levels of sVEGF were significantly higher in Diabetic with ED compared to healthy control and non-diabetic with ED groups. Additionally, statistically significant positive correlation was found between the concentration of sVEGF and the concentrations of TG and 2hPPBG, moreover Negative correlation was found between the concentration of sVEGF and the serum testosterone. No significant differences in the mean concentrations of sVEGF between the patients with ED plus DM and the patients with DM but no ED. sVEGF concentrations were not significantly correlated with the presence and severity of ED.