الفهرس 
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Abstract
Daily sedation interruption and targeting light sedation levels are safe and proven to improve outcome for sedated ICU patients. Therefore, the aim of this study to evaluate the effect of daily interruption of sedation on outcome of mechanically ventilated patients .The design of this study was quasi experimental research design. This study was carried out in (Trauma, General and Critical care ICUs) at Assiut university hospital. A convenience sampling of 60 adult’s critical ill patients aged from (18-60 years old) who admitted to previous mentioned setting who were eligible for inclusion in the subject. Subject was assigned to two equal groups each group consist of 30 patients. Control group who was received continuous sedation infusion, study group who was received daily interruption of sedation. Four tools were utilized to collect data, which are: tool I: - Patient assessment sheet. Tool II: Interruption and infusion sedation assessment tool. Tool III: RIFLE scale. Tool IV: Intensive Care Delirium Screening Checklist. A pilot study carried out in order to assess the feasibility and applicability of the tools and the necessary modifications were done. The pilot study was done on 6 patients were excluded from the study. The main results:- • Maintaining light levels of sedation in adult ICU patients is associated with improved clinical outcomes —Shorter duration of mechanical ventilation. — Shorter ICU length of stay. Decrease occurrence of respiratory complication. Regarding to Four Score Scale (FSS), results revealed that there was improvement of conscious level in study groups in all days rather than in control groups. According to Richmond Agitation Sedation Scale (RASS). Regarding Unarousable, It was noticed that there was a statistical significant difference between study and control groups. Related to weaning readiness criteria, my results revealed that there was a statistical significant difference between study and control groups in 4th and 5th days in majority of criteria.