الفهرس 
Beta-ThalassemiaOnly 14 pages are availabe for public view
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Abstract
Summary
Thalassemia is a genetic disorder characterized by a relative or
complete lack of α- or β-globin chains. It is characterized by chronic
ineffective erythropoiesis and anemia which requires lifelong blood
transfusions and involves a variety of complications associated with iron
overload, nutritional deficiencies and chronic oxidative stress, including the
neurological complications. In most cases, these complications remained
subclinical and were detected only during electrophysiological, or
neuroimaging evaluation.
Electrophysiological assessment, electroencephalogram (EEG),
magnetic resonance imaging (MRI) and transcranial Doppler (TCD) flow
studies are useful in detecting subclinical neurological complications, and to
predict strokes by detecting arterial stenosis with TCD
This study was carried out in the Neuropsychiatry and Pediatric
Departments, Tanta University Hospital, in the period from March 2018 to
March 2019
The aim of this work was to detect the neurological complications of
β-TM children.
This study was designed to include three groups:
A. group I: (25) children with β-TM. They were receiving packed cell
transfusion to maintain their hemoglobin concentration more than 9
gm/dL. They also received deferasirox as an oral iron chelating agent at a
dose ranging between 20-40 mg /kg/day and supportive therapy in the