الفهرس 
Introduction
Physiology of cerebrospinal fluid flowOnly 14 pages are availabe for public view
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Abstract
Background : Idiopathic intracranial hypertension (IIH) is a disease of unidentified etiology that mainly affects obese females in the childbearing period. Headache, visual problems, bilateral papilledema and pulsatile tinnitus are the most common IIH symptoms and permanent visual loss is the most important complication. The IIH is more common in females and its incidence is 1-2/100,000. Advancement of MRI techniques in current years especially Phase-Contrast Cine Magnetic Resonance Imaging (PCC- MRI) has expanded our knowledge about CSF flow using phase sensitive methods and anatomical structures such as aqueduct of sylvius, where CSF flow is the most regular, ventricular system and subarachnoid spaces. PCC- MRI can detect CSF flow even if it is very slow. Also, it can detect quantity of the flow Patients and Methods : This is a case control study carried out on patients with idiopathic intracranial hypertension to evaluate dynamic cerebrospinal fluid (CSF) flow changes in aqueduct of Sylvius using phase contrast cine (PCC) MRI. The study was conducted on 40 Egyptian patients at Neurology department, Mansoura University Hospital from August 2017 to September 2018. The patients were divided into 4 groups. The first (group 1) was ten (10) naive IIH patients (with no medical treatment nor frequent lumbar tapping). The second (group 2) was ten (10) known IIH patients on medical treatment. The third (group 3) was ten (10) known IIH patients on medical treatment and frequent lumbar tapping. The fourth (group 4) was Ten (10) control cases
Results: There were statistically significant difference between the group on medical treatment and the control group regarding the PDV; and between all studied groups regarding the mean flow. The MF was significantly higher in 1st discovered group than other groups. The PSV, PDV, SV were significantly higher in group who was on medical treatment than other groups.
Conclusion: In our study which was carried on 30 IIH patients and 10 control we found that the most specific CSF flowmetry parameter to diagnose IIH is mean flow and it was significantly higher in 1st discovered IIH group than other IIH groups. So we concluded that PCC MRI can be used as non-invasive technique for diagnosis of IIH.