الفهرس 
Gestational DiabetesOnly 14 pages are availabe for public view
 |  | from | 137 |  |  |
| | | from | 137 | | |
Abstract
Background: Omentin-1 a new anti-inflammatory adipokine has been identified as a major visceral (omental) secretory adipokine which plays important roles in glucose homeostasis, lipid metabolism, insulin resistance and diabetes. The aim of our study was to evaluate serum omentin-1 levels in Gestational diabetes and assess its relation with glycemic control, insulin resistance and metabolic parameters. Patients and Methods: The study included 25 women with gestional diabetes was diagnosed according to the WHO 2013 criteria, 25 pregnant women with normal glucose tolerance and 25 healthy non pregnant female of matched age as a control group. They were subjected to full history taking and clinical examination. Fasting (blood glucose, insulin, lipid profile, and omentin-1) and 2 hour Oral glucose tolerance test with 75g glucose were measured. HOMA-IR was calculated. Data was analyzed and expressed in terms of mean ± SD. Pearson correlation was performed to study the correlation of serum omentin-1 in relation to glycemic control, insulin resistance and metabolic parameters in the studied groups. Conclusion: Serum Omentin was negatively correlated with fasting insulin level and HOMA-IR both in cases and in patient group. This suggests that Omentin has a role in insulin resistance. There was a high significant negative correlation between Omentin and glycemic control, total cholesterol, triglyceride and LDL (P value <0.01) and high significant positive correlation between Omentin and HDL (P value <0.01) in all studied groups. The best cut off point of serum omentin was 177.8 ng/ml to differentiate cases from controls using ROC curve analysis.