الفهرس 
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Abstract
Tuberculosis (TB) is a serious infectious, contagious, airborne, chronic and
zoonotic disease, in 2018; 136 years have passed since the discovery
of Mycobacterium tuberculosis by Robert Koch as well as 25 years since the
WHO declared TB as a global health emergency. The worldwide
reemergence of DR-TB strains threaten TB control program; moreover the
emergence of drug-resistant M. bovis. Monitoring and tracking TB and DR-
TB is a critical component in the management of TB, because it allows the
identification of trends, challenges and implemented treatment program
successes, in areas that require additional attention.Our study is the first to
shed light on genotyping of circulating MDR strains in Egyptian community
using Whole Genome Sequencing (WGS). This study revealed that the
highest mono-resistance was detected against rifampicin (RIF), there one
MDR- M. bovis was detected, and the predominance of Euro-American
lineage in Egypt among drug resistance strain.