الفهرس 
Characteristics of malignant tumours
Targeted drugsOnly 14 pages are availabe for public view
 |  | from | 169 |  |  |
| | | from | 169 | | |
Abstract
Lung cancer is a one of the most cancer types spreaded worldwide. In Egypt, lung cancer counted as the third cause of deaths among males after liver and bladder cancers. Lung cancer characterized with two type’s SCLC represents about (10% to 15%) and NSCLCs which represents (80% to 85%). In NSCLCs, treatment only treat15%–30% of patients due to the presence of tumor mediators which enhance tumor surveillance by secreting PGE2, TGF-β. CD8+ and NK are the main cells to defeat and kill cancer cells. The aim of this study is to address the functionality of T-cells and NK cells on lung cancer patient’s pre and post stimulation in-vitro. Materials and methods Fifteen lung cancer patients and five healthy persons as volunteers were subjected to this study. Lung cancer patients were further classified into before5, during5 and after induction of chemotherapy5. Expression of GzB on CD3, CD4, CD8, NK, NKCD8 and NKCD8 cells before and after activation for 72 hrs in-vitro was determined. Results Data showed that after culture, there were highly significantly increased in the fold change in the percentage of GzB expression on CD3, CD4, CD8 and NKCD8 T cells in lung cancer patients before induction of chemotherapy compared to healthy control and other lung cancer patients. Conclusion: 1. Lung cancer is associated with decreased expression of GzB by infiltrating T cells, NK and NK T cells and this is possibly as a result of soluble factors produced by the cancer cells. 2. The effects of immunotherapy are relevant to induction of chemotherapy in definite method. 3. Functionality of CTL and NK cells are impaired in cancer patients during and after induction of chemotherapy. 4. Patients before induction of chemotherapy have the ability to improve their CTL and NK functionality under activation conditions. 5. The use of immune activation mechanism is needed before induction of chemotherapy.