الفهرس 
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Abstract
The main objective of the present work is to illustrate primarily three aspects:
A- Development of effective molluscicidal and antischistosomicidal drug which has a high curative power with minor side effects.
B- Assess the efficacy of miltefosine as chemical synthetic molluscicidal and antischisosomicidal drug in comparison with artemether as natural (plant in orgin) molluscicidal and antischistosomicidal drug in treatment of S. mansoni in B. alexandrina and albino mice.
C-Correlation of parasitological findings with biochemical, immunological and molecular observations before and after treatment with miltefosin and artemether drugs.
The recorded data in the present study demonstrated the following results:
I. The efficacy of of sublethal dose LC25 of miltefosine and artemether drugs on parasitological (biological) parameters of the intermediate host:
1. The sublethal dose LC25 of miltefosine (8.20 ppm) and artemether (11.04 ppm) drugs induced a marked significant increase in mortality rate and reduced the longevity of adult snails comparable as their infected control snails.
2. The prolonged exposure of the snails to miltefosine and artemether drugs has led to significant changes in the ability to lay eggs and the hatchability of eggs of treated B. alexandrina snails. The observed reduction of reproductive rate (Ro) and fecundity (MX) of treated B. alexandrina snails in the present study may be attributed to the negative effect of miltefosine and artemether on the histological structure of the ovotestis glands or gametogenic cells of the snails.