الفهرس 
Neonatal SepsisOnly 14 pages are availabe for public view
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Abstract
The present study was designed to evaluate cord blood copeptin level as a predictor of the occurrence of early-onset neonatal sepsis.
The study was conducted on 50 neonates, 30 neonates were diagnosed to have neonatal sepsis [21 males (70%) and
9 females (30%)], with mean gestational age (33.93±3.96 weeks), mean birth weight (1.91±0.73 Kg) and mean cord blood copeptin level (223.17±235.18 pg/ml).
A control group of 20 healthy neonates [14 males (70%) and 6 females (30%)], with mean gestational age (35.25±
2.05 wks), mean birth weight (2.46±0.62 Kg), mean cord blood copeptin level (95.00±38.97 pg/ml).
All patients in the study were subjected to adequate history taking, full clinical examination, CBC, CRP with titre, blood culture and cord blood copeptin assay.
In our study we found that cord blood copeptin level of septic neonates was significantly higher than those of the control group.
There was a significant positive correlation between cord blood copeptin level with Tollner & Rodwell scores, I/T ratio and CRP in sepsis group.
There was also a significant positive inverse correlation between cord blood copeptin level in cases group and platelets count.
The present study revealed that the best cutoff value of cord blood copeptin to detect sepsis was (85 pg/ml) with 73.3% sensitivity and 100% specificity.
This study also showed the prognostic value of cord blood copeptin in sepsis; it showed that cord blood copeptin was reliable as a prognostic tool in sepsis, with 54.5% sensitivity and 100% specificity.