الفهرس 
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Abstract
The present study was designed to evaluate Pleurotus ostreatus (PO) phenolic compounds and its biochemical effects on the DNA damage, expression level of some genes related to vascular complications and oxidative stress in STZ induced diabetic rats. Thirty two adult male albino rats were divided into 4 groups. group I Normal Control, group II non diabetic treated with PO, group III STZ induced diabetic rats, group IV STZ induced diabetic rats treated with PO. The concentration of phenolic compounds, blood glucose, tissue malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GPx), DNA fragmentation, and m-RNA expression levels of Nrf2 and VEGF genes were determined. A high performance liquid chromatography analysis detected five phenolic compounds, including Gallic acid, p-Coumaric acid, Ferulic acid, Fumaric acid and Chlorogenic acid. Our results revealed that the methanolic extract of PO significantly decreased blood glucose level, tissue MDA and DNA fragmentation with significant increase in GSH content and GPx activity and gene expression of Nrf2 and VEGF. In conclusion PO might be considered a potential protectant that reduce the oxidative stress associated with the diabetes complications in rats.