الفهرس 
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Abstract
The aim of the study is to evaluate different doses of propofol in xylazine- ketamine premedicated dogs. The study was carried out on 11 mature clinically healthy mongrel dogs (6 dogs for Preliminary work) and (5 dogs for Anesthetic protocol). The dogs were subjected to three different treatments with 14 days interval. The three different treatments were as followings:
Firstgroup: I.V combination of ketamine (2 mg/kg.b.w), and xylazine (0.5 mg/kg.b.w) then 15 minutes interval followed by IV injection of propofol (4 mg/kg.b.w).
Secondgroup: I.V combination of ketamine (2 mg/kg.b.w), and xylazine (0.5 mg/kg.b.w) then 15 minutes interval followed by IV injection of propofol (6 mg/kg.b.w).
Thirdgroup: I.V combination of ketamine (2 mg/kg.b.w), and xylazine (0.5 mg/kg.b.w) then 15 minutes interval followed by IV injection of propofol (8 mg/kg.b.w).
The physical, hematological and biochemical parameters were evaluated before (T0), after xylazine-ketamine, propofol administration and after recovery.
The results of this study revealed
Physical parameter
group 1
In body temperature, there was no significant variation except only significant decrease of body temperature between propofol 20 minutes and propofol 40 minutes. There were significant changes in heart rate along the time of anesthesia. There was a significant decrease in heart rate after xylazine –ketamine administration relative to the basal heart rate, and then it increased significantly after 10 minutes of propofol administration. Also, the respiratory rate showed a significant variation.There was a significant decrease in respiratory rate after xylazine –ketamine administrationthen gradually increased after propofol administration but non-significantly.
group 2
The physical parameters (temperature, heart rate and respiratory rate) did not show any significant changes either after xylazine-ketamine or propofol administration relative to the values before anaesthesia.
group 3
The temperature and heart rate in the third group which received 8 mg/kg of propofol did not change substantially. Concerning to, therespiratory rate there was a significant variation. It showed significant decrease after xylazine –ketamine administration which continued till 10 minutes passed after propofol administration then significant increases were recorded till recovery.
Duration and onset
There were no significant changes between the three groups either in the onset and duration. It was summarized in table. It was noticed that two dogs in the first group suffered vomiting after injection of xyalzine administration. In the other two groups, no animal had vomiting. The apnea (stop of respiration) was recorded in all animals in the group 2 and 3, while just two animals suffered apnea in group one.
chemical parameters
group 1
In serum biochemical constituents in dogs there was a significant increase (P<0.05) in serum GGT activity after recovery from administration of 0.5ml/kg b.w of xylazine, 2 ml/kg b.w. of ketamine and 4 ml/kg .b w. of propofol. The lipid profile showed a significant decrease in serum total cholesterol and LDL level (P<0.05) after recovery from administration of 0.5ml/kg b.w of xylazine, 2 ml/kg b.w. of ketamine and 4 ml/kg .b w. of propofol. Blood picture in dogs, there was a significant decrease in hemoglobin concentration and in MCHC (P<0.05) after recovery from administration of 0.5ml/kg b.w of xylazine, 2 ml/kg b.w. of ketamine and 4 ml/kg .b w. of propofol.
group 2
There were no significant changes in all measured blood constituents.
group 3
There were no significant changes in all measured blood constituents.